P-393 Gastric cancer metastasis patterns and racial disparities: SEER database population study 2010-2019

Metastasis is a poor prognostic factor for gastric cancer. Disparities between African-Americans and Caucasians in metastasis patterns require further investigation. Thus, this study aims to compare the of among different histological subtypes We obtained data 38,625 patients from Surveillance, Epidemiology, End Results Program (SEER) database 2010-2019. extracted with adenocarcinoma, signet ring cell carcinoma, stromal sarcoma carcinoid tumor who presented bone, brain, liver, or lung at time diagnosis. calculated relative risk (RR) confidence interval (CI) using SPSS software, version 25.0 (IBM). Liver was most common site across Adenocarcinoma prevalent subtype Compared African-Americans, adenocarcinoma had higher bone brain (RR=1.35, 95% CI 1.13-1.62, P=0.001 RR=1.96, 1.18 3.26, P=0.008, respectively) (Table 1). On other hand, lower liver (RR=0.86, 0.80-0.92, P>0.001). Additionally, also (RR=0.74, 0.61-0.90, P=0.004). Signet carcinoma showed no statistically significant differences regarding metastasis. Across multiple cancer, subtype, it varying tendencies African-Americans. Such discrepancy metastatic behavior races can guide, even prioritize, screening modalities patients. It warrants studying patients’ genetic biological factors.